Notification record (significant holdings)

Previous notifications of rights to vote and financial Instruments (ORYZON GENOMICS, S.A. )

Total number of voting rights (including attributed additional voting rights due to loyalty shares): 90,806,582

Of which:

   - attributable to shares: 84,332,150

   - additional granted due to loyalty shares: 6,474,432

Date of last modification of the total number of voting rights: 07/07/2026

Date of publication on the website CNMV: 21/07/2026

CVI INVESTMENTS, INC.

Total % acciones (A)	Total % Inst. financieros (B)	Total A+B	Información adicional	Register Number	Date of entry in the CNMV's registry
0.000	0.000	0.000		2025113961	03/09/2025
0.998	0.000	0.998		2025113959	03/09/2025
1.315	0.000	1.315		2025113909	03/09/2025
0.944	0.000	0.944		2025110228	14/08/2025
1.964	0.000	1.964		2025113906	03/09/2025
2.309	0.000	2.309		2025113903	03/09/2025
1.938	0.000	1.938		2025107783	05/08/2025
2.959	0.000	2.959		2025105909	31/07/2025
3.539	0.000	3.539		2025098433	18/07/2025
3.539	0.000	3.539		2025098139	17/07/2025
4.997	0.000	4.997		2025088524	27/06/2025
5.947	0.000	5.947		2025077251	06/06/2025
6.948	0.000	6.948		2025069881	16/05/2025
6.948	0.000	6.948		2025069333	15/05/2025
7.876	0.000	7.876		2025068306	13/05/2025
7.876	0.000	7.876		2025065193	06/05/2025
7.876	0.000	7.876		2025064163	05/05/2025